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首页> 外文OA文献 >Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP
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Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP

机译：组蛋白乙酰转移酶p300 / CREB结合蛋白（CBP）相关因子和CBP对同源域CCAAT置换/剪切蛋白功能的调节

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The CCAAT displacement protein/cut homologue (CDP/cut) is a divergent homeodomain protein that is highly conserved through evolution and has properties of a potent transcriptional repressor. CDP/cut contains three conserved cut-repeat domains and a conserved homeobox, each involved in directing binding specificity to unique nucleotide sequence elements. Furthermore, CDP/cut may play a role as a structural component of chromatin through its direct interaction with nucleosomal DNA and association with nuclear matrix attachment regions. CDP/cut is cell-cycle regulated through interactions with Rb, p107, specific kinases and phosphatases directing the transcriptional activity of CDP/cut on such genes encoding p21WAF1,CIP1, c-myc, thymidine kinase, and histones. Our previous studies indicate that CDP/cut is associated with histone deacetylase activity and is associated with a corepressor complex through interactions with histone deacetylases. Here, we report the interaction of CDP/cut with CBP and p300/CREB-binding protein-associated factor (PCAF) along with the modification of CDP/cut by the histone acetyltransferase PCAF. Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function. These observations are consistent with the ability of CDP/cut to regulate genes as a transcriptional repressor, suggesting acetylation as a mechanism that regulates CDP/cut function.
机译：CCAAT置换蛋白/剪切同源物（CDP / cut）是一种异源同源结构域蛋白，通过进化高度保守，并具有有效的转录阻遏物特性。 CDP / cut包含三个保守的cut-repeat域和一个保守的同源盒，每个都涉及将结合特异性引导至独特的核苷酸序列元件。此外，CDP / cut可能通过其与核小体DNA的直接相互作用以及与核基质附着区的缔合而充当染色质的结构成分。 CDP / cut通过与Rb，p107，特异性激酶和磷酸酶的相互作用来调节细胞周期，从而指导CDP / cut对此类编码p21WAF1，CIP1，c-myc，胸苷激酶和组蛋白的基因的转录活性。我们以前的研究表明，CDP / cut与组蛋白脱乙酰基酶活性有关，并且通过与组蛋白脱乙酰基酶的相互作用而与心脏加压复合物相关。在这里，我们报告CDP / cut与CBP和p300 / CREB结合蛋白相关因子（PCAF）的相互作用，以及通过组蛋白乙酰基转移酶PCAF修饰CDP / cut。 PCAF对CDP / cut的乙酰化作用是针对同源域附近的保守赖氨酸残基，并调节CDP / cut的功能。这些观察结果与CDP / cut调节作为转录阻遏物的基因的能力一致，表明乙酰化是调节CDP / cut功能的机制。

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